Okekunle, A.P.Asowata, O.J.FAKUNLE, A.G.Akpa, O.MAkpalu, AWahab, K.W.Ogunmodede, James AyodeleOlalusi, O.V.et al2023-05-212023-05-212022Journal of the Neurological Sciences 443:2022 (120489):1-5https://uilspace.unilorin.edu.ng/handle/20.500.12484/10604Background: Stroke is a leading cause of disability and mortality worldwide, but little is known about the contribution of secondhand smoke exposure (SHSE) to stroke epidemiology among indigenous Africans. Objective: To evaluate the association of SHSE with stroke among indigenous Africans. Methods: We analyzed the relationship of SHSE with stroke among 2990 case-control pairs of adults who had never smoked (identified in the SIREN study) using conditional logistic regression at a two-sided P < 0.05. Results: Multivariable-adjusted odds ratio and 95% confidence interval; 1.25 (1.04, 1.50; P = 0.02) revealed SHSE was positively associated with stroke independent of stroke subtypes. Conclusion: Culturally relevant primary prevention strategies targeted at SHSE might be promising in preventing stroke among Africans.stroke, secondhand smoking, SIRENArticle