Ayinde, T.O.,Olayaki L.A.,Ojulari, L.S.,Afodun, A.M.,Quadri, K.K.Fapounda, T2024-04-232024-04-232018Testosterone Supplementation, Renal function, Electrolyte, Urea, Creatinine.(Print): 2672-5193, (Online): 2736-1357https://uilspace.unilorin.edu.ng/handle/123456789/12676Objectives: Testosterone is an anabolic steroid and it is secreted primarily by the testicles in males. Androgens have been shown to increase tubular sodium and water reabsorption and activate various vasoconstrictor systems in the kidneys. Testosterone increases blood pressure and may also influence renal electrolyte excretion. Methods: Fifteen adult male rats weighing 100 – 150g were randomly divided into three groups of five (5) rats each. Group 1 rats (Control) were given normal saline intramuscularly (IM). Group 2 rats were given 3mg/kg body weight (bw) of testosterone IM while Group 3 rats were given 9mg/kg bw testosterone IM for two weeks. All rats were allowed normal chow and water ad libitum. The animals were sacrificed under anaesthesia and blood samples collected through cardiac puncture. Results: Plasma urea levels of both low (2.02±0.23mmol/L) and high (10.3±0.61mmol/L) dose testosterone-treated animals were higher when compared with the Control group (1.94±0.07mmol/L), but the difference was only significant (p<0.05) in the high dose group. Asignificant (p<0.05) increase in plasma creatinine level in animals injected with low dose testosterone (33.0±2.46µmol/L) and high dose testosterone (46.0±5.67µmol/L) was observed when compared to the control group (25.2±3.91µmol/L). Conclusion: It was concluded from this study that exogenous administration of testosterone may alter normal kidney functions shown by elevated levels of urea and creatinine, but these could also be dose dependenArticle