Odetunde, O.Ibrahim, M. O.2021-05-062021-05-0620166. Odetunde, O. and Ibrahim, M.O. (2016). Sensitivity analysis applied to the progression (deterioration) rate of Hepatitis B to primary liver cancer. Journal of Mathematical Sciences 4(1) 907 – 918. Published by the National Mathematical Centre, Abujahttps://uilspace.unilorin.edu.ng/handle/20.500.12484/4975We aimed at studying the sensitivity analysis of the parameters to the effective reproduction number for the rate of progression of Hepatitis B virus (HBV) to primary liver cancer. The effect of vaccination , sensitization and proper education on HBV transmission was considered as control strategies on the transmission rate of the disease. Also, the effect of therapeutic treatment was considered on the rate at which the the patients living with HBV progresses to a primary liver cancer patients. Positivity of solution of the model as well as the disease free equilibrium and endemic equilibrium states of the model were discussed.Threshold analysis of some of the parameters were analysed and discussed.enSensitivity AnalysisReproduction numberHBVPrimary liver cancerthreshold analysisArticle