Odetunde, O.Ibrahim, M. O.Lawal, J.Edogbanya, H. O.Akinyemi, S. T2019-10-182019-10-182015Mathematical modeling of Hepatitis B transition to primary liver cancer with consideration of partial immunity. Journal of the Nigerian Association of Mathematical Physics 32 211 – 220. Published by the Nigerian Association of Mathematical Physics.http://hdl.handle.net/123456789/2822This work study the rate of progression of Hepatitis B to Primary Liver Cancer, the effect of therapeutic treatment on the HBV and the role of vaccination of pregnant women as passive immunity for the unborn child. The equilibria states of both the disease free and the endemic were calculated. Positivity of the solution of the model was analyzed and the effective reproduction number was computed. The analysis of the reproduction number at the DFE indicated a substantial decrease in the number of secondary infection rate as a result of passively acquired immunity of the infant and the therapeutic treatment now available to HBV. However, the study show that the rate of progression to primary liver cancer (PLC) will be on the increase if the treatment is not affordable to all HBV patientsenHepatitis BPrimary Liver CancerPassive immunityreproduction numberpositvity of solutionArticle