Omotoso, Gabriel OlaiyaAlabi, ASOyabambi, AO2018-06-082018-06-08201312(2):50-52DOI: 10.4103/1596-2393.127957http://www.jecajournal.org/article.asp?issn=1596-2393;year=2013;volume=12;issue=2;spage=50;epage=52;aulast=Omotosohttp://hdl.handle.net/123456789/431Background: The testicular cytoarchitectural effects of albendazole administration were studied in adult Wistar rats. Materials and Methods: The animals were grouped into three groups, with six (6) rats per group. While animals in the control group A were given water, the treatment groups B and C received 15 mg/kg and 30 mg/kg respectively of albendazole orally for three consecutive days. The animals were sacrificed by cervical dislocation about 24 hours after drug administration, and the testes removed, fixed in 10% formal saline and processed for histological consideration, using Haematoxylin and Eosin stains. Results: Varying degrees of histological changes were noticed in the seminiferous tubules, which were marked in the group that received the higher dose of the drug. Conclusion: These structural distortions and degenerations of testicular tissues that occurred after albendazole administration are dose-dependent, and could affect reproductive functions in males.enAlbendazolehistologytestesWistar ratsArticle