Aiyelero, Oyeronke MedinatIbrahim, Zainab GamboYaro, Abdullahi Hamza2023-05-052023-05-052009https://uilspace.unilorin.edu.ng/handle/20.500.12484/9545Ficus ingens is a medicinal plant used for haemorrhoids, in Borno State of Nigeria. In the present study, the analgesic and anti-inflammatory activities of methanol leaf extract of Ficus ingens, (Miq.) Miq., (at doses of 75, 150, and 300 mg/kg i.p.) were evaluated using acetic acid- induced writhing test and hot plate in mice, and carragenan- induced paw oedema in rats. The extract at all doses tested significantly (P<0.001) inhibited acetic acid-induced writhing and also significantly (P<0.05) prolonged the reaction latency to pain thermally induced in mice by the hot plate. The extract at the doses (75, 150, and 300 mg/kg i.p.) tested afforded 61, 72, and 67% inhibition of paw oedema, respectively at the end of the third hour which implied that the extract inhibit the release of prostaglandins and lysosomal enzymes. The intraperitoneal median lethal dose (LD50) value in mice was 1131.4 mg/kg suggesting that the extract is relatively non-toxic at doses used. The phytochemical screening revealed the presence of alkaloids, flavonoids, glycosides, saponins and tannins which might be responsible for the observed analgesic and anti-inflammatory activity. This study showed that Ficus ingens possesses significant anti-inflammatory and analgesic properties in rodents which supported the folkloric claim for the use of the plant in the management of haemorrhoids.enFicus ingens, Analgesia, Anti-inflammation, Phytochemical screening, Acute toxicityArticle