Ayanniyi, RashidatWannang, Noel2019-10-182019-10-182008http://hdl.handle.net/123456789/2848To determine the neuropharmacological activity of the leaf extract of Croton zambesicus in mice and chicks. The effect of aqueous leaf extract of Croton zambesicus on thiopental sodium-induced sleeping time in mice, on gross locomotor activity (GLA) in 2-day old chicks and effect of extract on apomorphineinduced stereotyped behaviour in chicks were evaluated. The aqueous extract (1000 and 1500 mg/kg) administered per os (p.o) prolonged the thiopental sodium-induced sleeping time in mice. Extract (20-40 mg/kg i.p) produced a significant p<0.05 decrease in GLA in 2-day old chicks in a dose dependent manner. 40-60 mg/kg administered intraperitoneally (i.p) produced sedation and sleep with a significant p<0.05 decrease in onset and an increase in duration of sleep. The extract administered subcutaneously (s.c.) had an insignificant p>0.05 effect on apomorphine-induced stereotyped behaviour in chicks. These results suggest that leaf extract of Croton zambesicus possesses CNS depressant, sedative, and hypnotic activity.enCroton zambesicuscentral nervous systemdepressantsedativehypnoticArticle