Omotoso G.O.Kadir R.E.Lewu S.F.Gbadamosi I.T.Akinlolu A.A.Adunmo G.O.Kolo R.M.Lawal M.O.Ameen M.O.2025-05-022025-05-022018Omotoso G.O., Kadir R.E., Lewu S.F., Gbadamosi I.T., Akinlolu A.A., Adunmo G.O., Kolo R.M., Lawal M.O. & Ameen M.O. (2018): Moringa oleifera ameliorates cuprizone-induced cerebellar damage in adult female rats. Research Journal of Health Sciences. 6(1):13-25. Published by College of Health Sciences, Osun State University. Available online at: https://www.ajol.info/index.php/rejhs/issue/view/169122467-8252https://uilspace.unilorin.edu.ng/handle/123456789/15887Objectives: Cuprizone is a neurotoxicant used in modeling demyelinating disorders. This study explored the effects of Moringa oleifera (MO) on oxidative, histomorphological and behavioural changes in cuprizone-damaged cerebellum. Methods: Twenty adult female Wistar rats were grouped into 4, each group having five animals. Group A received 1 ml of normal saline (Control); group B received 0.4% cuprizone; group C received 15.6 mg/kgBW Moringa oleifera leaf extract; group D received 0.4% cuprizone and 15.6 mg/kgBW Moringa oleifera, orally for 5 weeks. The animals were assessed for exploratory and locomotor activities, while the cerebellum was processed for histology and assayed for nitric oxide (NO), catalase (CAT) and superoxide dismutase (SOD) activities. Results: Cuprizone treatment caused weight reduction, disruption of Purkinje cell layer, cellular degeneration, reduction in NO, CAT and SOD activities. However, these changes were ameliorated when co-administered with MO. Conclusion: The anti-oxidative property of Moringa oleifera is responsible for its ameliorative effect in cuprizone neurotoxicity.endemyelinationcuprizonecerebellar damageMoringa oleiferaoxidative enzymesArticle