Ajiboye, T.O., Akinpelu, S.A., Muritala, H.F., Ogunbode, S.M., Adeleye, A.O., Oladiji, A.T. and Oloyede, O.B.2023-04-112023-04-1120141745-4514https://uilspace.unilorin.edu.ng/handle/20.500.12484/9070The effect of Trichosanthes cucumerina fruit pulp extract on dyslipidemia, protein oxidation, lipid peroxidation and DNA fragmentation in the liver of high-fat diet-fed rats was investigated. High-fat diet-mediated alterations in liver and serum total cholesterol, triacylglycerol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, very-low-density lipoprotein cholesterol, alkaline phosphatase, and alanine and aspartate aminotransferase were significantly (P 0.05) reversed by the T. cucumerina pulp extract. The extract increased the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glucose 6-phosphate dehydrogenase in the mitochondria and post-mitochondria fractions of rat liver. The increase significantly (P 0.05) attenuated high-fat diet-mediated reductions in antioxidant enzyme activities. High-fat diet-mediated elevation in the levels of conjugated dienes, lipid hydroperoxides, malondialdehyde, protein carbonyl and DNA fragmentation in rat liver was dose-dependently lowered by the extract. The data obtained from this study showed that the T. cucumerina fruit pulp extract palliated highfat diet-mediated dyslipidemia, protein oxidation, lipid peroxidation and DNA fragmentation in rats.enTriacyl glycerol,Article