Soji-Omoniwa, OOloyede, H.O.B2023-06-302023-06-3020160794-0378https://uilspace.unilorin.edu.ng/handle/20.500.12484/11384The effect of Ficus exasperata leaf-based diet on antioxidant parameters of type 2 diabetic rats was investigated in this study. Forty-eight (48) male albino rats were randomly selected into 8 groups, namely A to H. Various proportion (10, 20, 30, 40 and 50%) of Ficus exasperata powerdered leaf was incorporated into locally sourced ingredients and formulated into feed. The feed was administered ad libitum to animals in group D to H, after induction of diabetes using 10% fructose solution ad libitum and 40 mg/kg b.wt. streptozotocin injected intraperitoneally. Group A (positive control), B (negative control) and C (metformin-treated group) received feed without F. exasperata leaf. Biochemical parameters studied are; Fasting Blood Glucose (FBG), Superoxide dismutase, Catalase, Reduced glutathione and Malondialdehyde (MDA). Data analysis was done with SPSS version 16.0 and level of significance set at p<0.05. Results showed alteration in the endogenous antioxidant parameters of diabetic animals when compared to the positive control. Treatment of the experimental animals with test diets resulted in a significant (p<0.05) increase in the activity of superoxide dismutase, catalase and reduced glutathione level when compared to the negative control and no significant difference (p>0.05) compared to the positive control group. MDA concentration was significantly reduced (p<0.05) for all the treatment groups as well, compared to the negative control. In conclusion, Feeding of Ficus exasperata leaf-based diet to Type 2 diabetic rats for 16 days ameliorated the alteration in the endogenous antioxidant parameters studied. There was no significant difference in the ameliorative effect of the various proportion of the Ficus exasperata leaf in the feed.en-USFicus exasperata LeafAntioxidant parametersType 2 diabetesArticle