| dc.description.abstract | Therapeutic properties of medicinal plants are very useful in the treatment and
healing various diseases and the advantaged of these plants is been 100% natural with little or
no side effects. The present study seeks to investigate the biochemical and antioxidant effects
of aqueous leaf extract of Talinum triangulare (water leaf) in female Sprague -Dawley rats.
Twenty Four (24) female Sprague -Dawley rats weighing 150-180gram were grouped into 4 of 6
rats each. Group A: control; administered (10ml/kg body weight) of normal saline. The other
groups were administered the aqueous leaf extract of Talinum triangulare thus: group B -
50mg/kg, group C - 100mg/kg, and group D – 150mg/kg. After fourteen (14) days, blood
samples were collected for lipid and antioxidant analysis. The results revealed significant
increase in AST (aspartate amino transferase) at 150ml/kg, when compared with the group A
S(P>0.05). The ALT (alanine amino transferase) was significantly decreased (P>0.05) at 100ml/kg
when compared with group A and group B with significant elevation at 150ml/kg. The ALP
(alkaline phosphatase) was significantly increased in all the tested doses (P>.0.05). Results from
the lipid profile analysis showed significant decrease in all the doses tested (P>0.05) for
cholesterol (CHOL), triglyceride (TG) and high density lipoprotein (HDL) levels except for CHOL
and HDL which showed significant increase (P>0.05) at 150ml/kg. The low density lipoprotein
(LDL), protein, and albumin levels showed significant increase in the tested doses expect,
protein and albumin which was significantly decreased (P>0.05) at 100ml/kg and 150ml/kg. Also
the creatinine level was significantly decreased in all the doses tested (P>0.05). The antioxidant
assay revealed significant increase in glutathione, GSH, superoxide dismutase, SOD and
Catalase, CAT (P>.05) at all doses, expect SOD which was significantly decreased at 150mg/kg.
The malondialdehyde, MDA was significantly decreased (P>0.05) in all the tested doses. Our
findings showed that aqueous leaf extract of Talinum triangulare administration at 50mg/kg,
100mg/kg and 150mg/kg have no adverse effect on renal functions. However, at 150ml/kg the
aqueous leaf extract of Talinum triangulare gave rise to increase in liver enzymes' activity,
increased low density lipoprotein as well as oxidative radical productions. Finally excessive
intake should be avoided since it is dose dependent because of its ability to increase risk of
obesity, cardiovascular disorder and liver damage. | en_US |
