Browsing by Author "Khan, F.A."
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Item A new ent-clerodane diterpene from Detarium microcarpum Guill. & Perr. and its protective potential for osteoporosis(2022) Irshad, R.; Kabbashi, A.S.A.; Salawu, K.M.; Cao, Y.G.; Fayaz, A.; Khan, F.A.; Choudhary, M.I.; Wang, Y.A new clerodane diterpene, named 6α-hydroxy-3,13E-clerodien-15-oic acid (1), together with a known clerodane diterpene (2), four known labdane diterpenes (3–6), a triterpenoid (7), a known steroid (8), and two benzenoid compounds (9 and 10) were isolated from Detarium microcarpum Guill. & Perr. The structures of all obtained compounds were determined by chemical properties and spectroscopic evidence, accompanied by comparisons with data in the literature. Electronic circular dichroism (ECD) was performed for compounds 1–4 to confirm the absolute configuration. Compounds 1–3 and 8–10 were evaluated for the protective effect on osteoblasts. Compound 1 was observed to increase the proliferation of dexamethasone (DEX)-treated MC3T3-E1 cells significantly at 1 μM, which was comparable with the positive control geniposide at 10 μM. The results were further confirmed by flow cytometry analysis. In addition, compound 1 increased the level of alkaline phosphatase (ALP) and mineralization in osteoblasts inhibited by DEX. Moreover, Compound 9 (vanillic acid) showed a pronounced inhibition (IC50 6.5 ± 0.6 μM) on reactive oxygen species (ROS) production, and 10 (4-O-methyl gallic acid) showed a good inhibition with IC50 as 103.3 ± 2.2 μM, compared with the standard drug ibuprofen (IC50 54.2 ± 9.2 μM). Besides, compounds 1–3 and 8–10 were non-cytotoxic against MCF-7, NCI-H460, Hela, and BJ cell lines.Item A new sesquiterpene, prosoterpene, from Prosopis africana (Guill. & Perr.) Taub.(Natural Product Research, 2022) Ali, R.; Salawu, K.M.; Aamer, M.; Jahan, H.; Tufail, P.; Irshad, R.; Khan, F.A.; Sener, B.; Choudhary, M.I.; Wang, YA new sesquiterpene (Prosoterpene, 1) and eleven reported compounds (2–12) of several classes, such as flavonoids, alkaloids, phenolic acids, and long-chain alcohols, were isolated from the BuOH extract of Prosopis africana (Guill. & Perr.) Taub. Compounds 2–10 were reported for the first time from this plant. Isomers 11 and 12 were separated for the first time. Extensive spectroscopic techniques and literature comparisons were used to characterise their structures. Furthermore, compounds 3, 5–8, and 10–12 were performed for anti-glycation and cytotoxicity activities. Compound 3 (quercetin-3-O-a-L-rhamnoside) exhibited moderate anti-glycation activity. All tested compounds were noncytotoxic against MCF-7 (breast cancer), NCI-H460 (lung cancer), Hela (cervical cancer), and BJ (normal human fibroblast) cell lines.Item Phytochemical Characterizations of Maranthes polyandra (Benth.) Prance.(Molecules, 2022) Ali, N.; Khan, F.A.; Salawu, K.M.; Irshad, R.; Jabeen, A.; Zhang, C.L.; Choudhary, M.I.; Liu, X.M.; Wang, Y.Two new ursane-type triterpenoids, named Polyanside A (1) and B (2), along with eleven known compounds (3–13), were isolated and elucidated from Maranthes polyandra (Benth.) Prance. The structures of these compounds were elucidated based on chemical evidence and multiple spectroscopic data. Isolated compounds were evaluated for anti-cancer, anti-inflammatory activities, and cytotoxicity on a normal human cell line (BJ). None of them showed activity and cytotoxicity. The hexane fraction was analyzed by GC-MS, resulting in the identification of forty-one compounds. This is the first comprehensive study on the phytochemistry of M. polyandra.