Browsing by Author "Gbadamosi, I. T."

Now showing 1 - 2 of 2
  • Item
    Moringa oleifera IS PROTECTIVE AGAINST MICROARCHITECTURAL AND NEUROCHEMICAL CHANGES ASSOCIATED WITH CUPRIZONEINDUCED PREFRONTAL CORTEX NEUROTOXICITY IN FEMALE WISTAR RATS
    (Neuroscience Society of Nigeria (NSN), 2018-05-20) Omotoso, G. O.; Gbadamosi, I. T.; Akinlolu, A, A.; Ameen, Mubarak; Kadir, R. E.; Jaji-Sulaimon, R.; Abdulwahab, A. B.; Kolo, R. M.
    Cuprizone administration causes selective damage to axonal myelin sheath and has been used to model demyelinating diseases in neuroscience research. This study aimed at determining the protective effects of Moringa oleifera on cuprizone-induced neurotoxicity in the prefrontal cortex (PFC). Sixteen adult female Wistar rats were procured and grouped into 4: Group A was given normal saline, Group B received 0.4% cuprizone diet, Group C was administered with 1.875 mg/ml of Moringa oleifera and Group D received a combination of 0.4% cuprizone diet and 1.875 mg/ml of Moringa oleifera. All the groups were treated orally for 35 consecutive days after which they were sacrificed. Thereafter the PFC was processed for histological demonstration, while tissue homogenate was used to assay the activity of superoxide dismutase (SOD). Cuprizone administration caused significant reduction in body weight and SOD activities. It also caused an alteration in the microarchitecture and Nissl profile of the PFC. Moringa oleifera intervention led to restoration of body weight, SOD levels, Nissl profile and the histology of the PFC. The use of preparations of Moringa oleifera, especially the leaf-component, could offer some protective measures to individuals suffering from demyelinating conditions, especially in addressing the associated weight changes and frontocortical dysfunction.
  • Item
    Research Journal of Health Sciences
    (2018-02-01) Omotoso, G. O.; Kadir, R. E.; Gbadamosi, I. T.; Akinlolu, A. A.; Adunmo, G. O.; Kolo, R. M.; Lawal, M. O.; Ameen, M. O.
    Objectives: Cuprizone is a neurotoxicant used in modeling demyelinating disorders. This study explored the effects of Moringa oleifera (MO) on oxidative, histomorphological and behavioural changes in cuprizone-damaged cerebellum. Methods: Twenty adult female Wistar rats were grouped into 4, each group having five animals. Group A received 1 ml of normal saline (Control); group B received 0.4% cuprizone; group C received 15.6 mg/kgBW Moringa oleifera leaf extract; group D received 0.4% cuprizone and 15.6 mg/kgBW Moringa oleifera, orally for 5 weeks. The animals were assessed for exploratory and locomotor activities, while the cerebellum was processed for histology and assayed for nitric oxide (NO), catalase (CAT) and superoxide dismutase (SOD) activities. Results: Cuprizone treatment caused weight reduction, disruption of Purkinje cell layer, cellular degeneration, reduction in NO, CAT and SOD activities. However, these changes were ameliorated when co-administered with MO. Conclusion: The anti-oxidative property of Moringa oleifera is responsible for its ameliorative effect in cuprizone neurotoxicity.