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Title: Anti-inflammatory and antipyretic properties of Corchorus olitorius aqueous root extract in Wistar rats
Authors: Bamidele V. Owoyele
Modupe L. Alimi
Shukurat A. Sanni
Sabitiu A. Oyeleke
Keywords: Anti-inflammatory; antipyretic
C orchorus olitorius
; Granuloma
Issue Date: 2015
Publisher: J Basic Clin Physiol Pharmacol
Abstract: Background: This study was designed to provide information about the antipyretic and anti-inflammatory effects of Corchorus olitorius root. Methods: Thirty male Wistar rats were divided into six groups of five animals each; the control and reference groups were administered normal saline (10 mL/kg) and indomethacin (5 mg/kg), respectively, whereas the remaining four groups were administered aqueous extract of C. olitorius at doses of 25, 50, 100, or 200 mg/kg, respectively. Pyrexia was induced by injecting 10 mL/kg of 20% (w/v) brewer ’ s yeast suspension into the dorsum of rats, whereas inflammation was induced through an injection of 0.1% carrageenan into the right hind paw of each rat and through a subcutaneous implantation of a 30-g sterilized cotton pellet into the groin of each rat. Results: The results showed that C. olitorius root extract (p < 0.05) decreased the elevated temperature after brewer’s yeast injection compared with the 17 h (pre-drug) temperature. In the inflammatory tests, the paw sizes and granuloma weights in the test groups were significantly (p < 0.05) decreased compared with the control group. Conclusions: Corchorus olitorius root is another good source of phytomedicine that can be used effectively to treat inflammation and pyrexia that accompany some diseases.
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